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Col, E.* ; Hoghoughi, N.* ; Dufour, S.* ; Penin, J.* ; Koskas, S.* ; Faure, V.* ; Ouzounova, M.* ; Hernandez-Vargash, H.* ; Reynoird, N.* ; Daujat, S.* ; Folco, E.J.* ; Vigneron, M.* ; Schneider, R. ; Verdel, A.* ; Khochbin, S.* ; Herceg, Z.* ; Caron, C.* ; Vourc'h, C.*

Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.

Sci. Rep. 7:5418 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The heat shock response is characterized by the transcriptional activation of both hsp genes and noncoding and repeated satellite III DNA sequences located at pericentric heterochromatin. Both events are under the control of Heat Shock Factor I (HSF1). Here we show that under heat shock, HSF1 recruits major cellular acetyltransferases, GCN5, TIP60 and p300 to pericentric heterochromatin leading to a targeted hyperacetylation of pericentric chromatin. Redistribution of histone acetylation toward pericentric region in turn directs the recruitment of Bromodomain and Extra-Terminal (BET) proteins BRD2, BRD3, BRD4, which are required for satellite III transcription by RNAP II. Altogether we uncover here a critical role for HSF1 in stressed cells relying on the restricted use of histone acetylation signaling over pericentric heterochromatin (HC).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Induced Nuclear-bodies; Gene-expression; P-tefb; Hsp70 Loci; In-vivo; Stress; Chromatin; Complex; Binding; Cells
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 7, Heft: 1, Seiten: , Artikelnummer: 5418 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Functional Epigenetics (IFE)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502800-001
PubMed ID 28710461
DOI 10.1038/s41598-017-05343-8
WOS ID WOS:000405464200055
Scopus ID 85024368566
Erfassungsdatum 2017-09-06
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