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Weng, L.C.* ; Lunetta, K.L.* ; Müller-Nurasyid, M. ; Smith, A.V.* ; Thériault, S.* ; Weeke, P.E.* ; Barnard, J.* ; Bis, J.C.* ; Lyytikäinen, L.-P.* ; Kleber, M.E.* ; Martinsson, A.* ; Lin, H.J.* ; Rienstra, M.* ; Trompet, S.* ; Krijthe, B.P.* ; Dörr, M.* ; Klarin, D.* ; Chasman, D.I.* ; Sinner, M.F.* ; Waldenberger, M. ; Launer, L.J.* ; Harris, T.B.* ; Soliman, E.Z.* ; Alonso, A.* ; Paré, G.* ; Teixeira, P.L.* ; Denny, J.C.* ; Shoemaker, M.B.* ; van Wagoner, D.R.* ; Smith, J.D.* ; Psaty, B.M.* ; Sotoodehnia, N.* ; Taylor, K.D.* ; Kähönen, M.* ; Nikus, K.* ; Delgado, G.E.* ; Melander, O.* ; Engström, G.* ; Yao, J.* ; Guo, X.* ; Christophersen, I.E.* ; Ellinor, P.T.* ; Geelhoed, B.* ; Verweij, N.* ; Macfarlane, P.W.* ; Ford, I.* ; Heeringa, J.* ; Franco, O.H.* ; Uitterlinden, A.G.* ; Völker, U.* ; Teumer, A.* ; Rose, L.M.* ; Kääb, S.* ; Gudnason, V.* ; Arking, D.E.* ; Conen, D.* ; Roden, D.M.* ; Chung, M.K.* ; Heckbert, S.R.* ; Benjamin, E.J.* ; Lehtimäki, T.* ; März, W.* ; Smith, J.G.* ; Rotter, J.I.* ; van der Harst, P.* ; Jukema, J.W.* ; Stricker, B.H.* ; Felix, S.B.* ; Albert, C.M.* ; Lubitz, S.A.*

Genetic interactions with age, sex, body mass index, and hypertension in relation to atrial fibrillation: The AFGen Consortium.

Sci. Rep. 7:11303 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10(-5)). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10(-8)). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 7, Heft: 1, Seiten: , Artikelnummer: 11303 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
G-504091-001
DOI 10.1038/s41598-017-09396-7
WOS ID WOS:000410297900017
Scopus ID 85029282039
PubMed ID 28900195
Erfassungsdatum 2017-09-25
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