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Becker, M. ; Levings, M.K.* ; Daniel, C.

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk.

Eur. J. Immunol. 47, 1867-1874 (2017)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Obesity and type-2 diabetes (T2D) are associated with metabolic defects and inflammatory processes in fat depots. FoxP3 + regulatory T cells (Tregs) control immune tolerance, and have an important role in controlling tissue-specific inflammation. In this mini-review we will discuss current insights into how cross-talk between T cells and adipose tissue shapes the inflammatory environment in obesity-associated metabolic diseases, focusing on the role of CD4 + T cells and Tregs. We will also highlight potential opportunities for how the immunoregulatory properties of Tregs could be harnessed to control inflammation in obesity and T2D and emphasize the critical need for more research on humans to establish mechanisms that are conserved in both mice and humans.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adipose Tissue Function ; Foxp3 ; Il-33 ; Immune-adipose Crosstalk ; Regulatory T Cells (tregs) ; T Cell Tolerance ; Type 2 Diabetes; Alternatively Activated Macrophages; Insulin-resistance; Reg Cells; Metabolic Disease; Obese Individuals; Human Adipocytes; Dendritic Cells; Ppar-gamma; Inflammation; Il-33
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Zeitschrift European Journal of Immunology
Quellenangaben Band: 47, Heft: 11, Seiten: 1867-1874 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Type 1 Diabetes Immunology (TDI)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502191-001
DOI 10.1002/eji.201646739
WOS ID WOS:000414677400003
Scopus ID 85030096902
PubMed ID 28849586
Erfassungsdatum 2017-10-09
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