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Hohberger, B.* ; Chaudhri, M.A.* ; Michalke, B. ; Lucio, M. ; Nowomiejska, K.* ; Schlötzer-Schrehardt, U.* ; Grieb, P.* ; Rejdak, R.* ; Jünemann, A.G.M.*

Levels of aqueous humor trace elements in patients with open-angle glaucoma.

J. Trace Elem. Med. Biol. 45, 150-155 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Purpose: Trace elements might play a role in the complex multifactorial pathogenesis of open-angle glaucoma. The aim of this study was to analyze concentrations of trace elements in aqueous humor samples of patients with primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG). Patients and methods: Thirty-three aqueous humor samples were obtained from patients undergoing cataract surgery: 12 patients with POAG (age 65.3 +/- 10.50, female 8, male 4), 10 patients with PEXG (age 65.9 +/- 11.27, female 6, male 4) and 11 patients without glaucoma (age 69.5 +/- 13.70, female 7, male 4) serving as controls. Aqueous humor levels of cadmium, iron, manganese, cobalt, copper and zinc were measured by Flow-Injection-Inductively-Coupled-Plasma-Mass-Spectrometry (FI-ICP-MS). Results: From the statistical evaluation, we observed that patients with POAG had significantly higher aqueous humor levels of zinc (p = 0.006) compared to controls. Increased aqueous humor levels of zinc were also observed in patients with PEXG in relation to control (p = 0.0006). For iron we observed a significantly reduction in PEXG compared to control (p = 0.002) and a significant difference between POAG and PEXG (p = 0.0091). No significant differences were observed in aqueous humor levels of manganese, cobalt, copper, cadmium between glaucoma and control patients. No differences were seen for iron (POAG vs. controls). Analysis of trace element ratios was added. Conclusion: Significant differences in aqueous humor levels of zinc and iron between glaucoma and control patients support the hypothesis that these trace elements are involved in the pathogenesis of open-angle glaucoma.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Trace Elements ; Pi-icp-ms ; Glaucoma ; Iron ; Zinc; Oxidative Dna-damage; Trabecular Meshwork; Pseudoexfoliation Syndrome; Iron-deficiency; Cell-death; Zinc; Copper; Stress; Antioxidant; Selenium
Sprache
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0946-672X
e-ISSN 1878-3252
Zeitschrift Journal of Trace Elements in Medicine and Biology
Quellenangaben Band: 45, Heft: , Seiten: 150-155 Artikelnummer: , Supplement: ,
Verlag Urban & Fischer
Verlagsort Jena
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit BioGeoChemistry and Analytics (BGC)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504800-002
DOI 10.1016/j.jtemb.2017.10.003
WOS ID WOS:000419812800021
Scopus ID 85032026874
PubMed ID 29173472
Erfassungsdatum 2018-01-24
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