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Heisler, L.K.* ; Lam, D.D.

An appetite for life: Brain regulation of hunger and satiety.

Curr. Opin. Pharmacol. 37, 100-106 (2017)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Obesity results from the consumption of food in excess of bodily energy requirements, with the excess energy stored as adipose tissue. Sequelae of obesity, such as heart disease and type 2 diabetes, consistently rank among the top causes of death worldwide. The global prevalence of obesity highlights the urgency of understanding the mechanisms regulating hunger and satiety. Appetite, defined as the motivational drive to obtain food, is regulated by a complex neurocircuitry which integrates a variety of interoceptive signals to gauge nutritional state and guide appropriate levels of food-seeking. Here we review key recent developments in the identification of cell groups, neural circuits, endogenous and exogenous substances, and intracellular signaling pathways which drive hunger and satiety. We also consider particularly promising pharmacological targets for appetite modulation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Nucleus-tractus-solitarius; Food-intake; Agrp Neurons; Hypothalamic Neurons; Pomc Neurons; Body-weight; Feeding-behavior; Neural Circuits; Activation; Leptin
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1471-4892
e-ISSN 1471-4973
Zeitschrift Current opinion in pharmacology
Quellenangaben Band: 37, Heft: , Seiten: 100-106 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Neurogenomics (ING)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503200-001
PubMed ID 29107871
DOI 10.1016/j.coph.2017.09.002
WOS ID WOS:000419423700017
Scopus ID 85032731166
Erfassungsdatum 2017-11-08
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