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Ferrari, U. ; Banning, F. ; Freibothe, I. ; Tröndle, K. ; Sacco, V. ; Wichmann, C. ; Reif, S. ; Moschko, S. ; Potzel, A. ; Gar, C. ; Sommer, N.N.* ; Popp, D.* ; Seissler, J. ; Lechner, A. ; Künzel, H.*

Depressive symptoms, impaired glucose metabolism, high visceral fat, and high systolic blood pressure in a subgroup of women with recent gestational diabetes.

J. Psychiatr. Res. 97, 89-93 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Women with gestational diabetes (GDM) are a high risk group for early type 2 diabetes (T2D). Depression is a risk factor for T2D in the general population. We investigated in women after a recent pregnancy with GDM and without a clinical diagnosis of depression, whether mild to moderate depressive symptoms associate with pathologic glucose metabolism. In a cross-sectional analysis, we examined 173 women, 9 3 months after delivery with several psychopathological assessments, 5-point oral glucose tolerance test with insulin, anthropometrics, and laboratory chemistry. In a subgroup of 101 women, abdominal visceral fat was quantified by magnetic resonance imaging (MRI). A total of 22 women (13%) showed mild to moderate depressive symptoms, and the proportion of women with pathologic glucose metabolism (impaired fasting glucose, impaired glucose tolerance, or T2D) was higher in this group than in the women without depressive symptoms (59.1% vs. 33.1%, p = 0.018). Women with depressive symptoms also had higher body mass index (BMI), systolic blood pressure, plasma leptin, plasma resistin, and abdominal visceral fat volume. Pathologic glucose metabolism (OR = 2.594, 95% CI: 1.021-6.592), systolic blood pressure (OR = 1.076, 95% CI: 1.027-1.128), and abdominal visceral fat volume (OR = 2.491, 95% CI: 1.142-5.433) remained, even after adjustment for BMI, associated with the presence of depressive symptoms. Taken together, we found depressive symptoms at a level not generally diagnosed in clinical practice in a subgroup of women with recent GDM. This subgroup also showed an unfavorable metabolic profile. Mild to moderate depressive symptoms may therefore help to identify this special subgroup.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Depressive Symptoms ; Prediabetes ; Gestational Diabetes ; Glucose Tolerance ; Metabolic Syndrome ; Visceral Fat ; Biomarkers; Antidepressant Medication; Major Depression; Glycemic Control; Sleep Quality; Risk-factor; Metaanalysis; Disorder; Germany; Prevalence; Tolerance
Sprache englisch
Veröffentlichungsjahr 2018
Prepublished im Jahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0022-3956
e-ISSN 1879-1379
Zeitschrift Journal of Psychiatric Research
Quellenangaben Band: 97, Heft: , Seiten: 89-93 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-521500-002
PubMed ID 29223020
DOI 10.1016/j.jpsychires.2017.12.001
WOS ID WOS:000423646600014
Scopus ID 85036668107
Erfassungsdatum 2018-01-24
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