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Eisenhofer, S. ; Hense, B.A. ; Toókos, F. ; Zischka, H.

Modeling the volume change in mitochondria.

Int. J. Biomath. Biostat. 1, 53-62 (2010)
Mitochondrial swelling due to permeability transition is an important biological phenomenon with a lot of open questions. We give a new mathematical approach to model the volume change during the process. As opposed to the existing models we do not use differential equations, just basic assumptions about the swelling of a single mitochondrion and its cumulative effect. The results accurately describe the experimental swelling curves and are in accordance with previous findings. They also provide more insight into the nature of the positive feedback in the process. Due to its simplicity the method can be used for other biochemical or population dynamical processes as well.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mitochondrial swelling; Mathematical modeling; Parameter estimation; Feedback
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0973-7340
Zeitschrift International Journal of Biomathematics and Biostatatistics
Quellenangaben Band: 1, Heft: 1, Seiten: 53-62 Artikelnummer: , Supplement: ,
Verlag Serials Publ.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biomathematics and Biometry (IBB)
Institute of Molecular Toxicology and Pharmacology (TOX)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e) G-503800-002
G-505200-001
Erfassungsdatum 2010-11-17
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