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Castañeda-Tamez, P.* ; Ramírez-Peris, J.* ; Pérez-Velázquez, J. ; Kuttler, C.* ; Jalalimanesh, A.* ; Saucedo-Mora, M.A.* ; Jiménez-Cortés, J.G.* ; Maeda, T.* ; González, Y.* ; Tomás, M.* ; Wood, T.K.* ; García-Contreras, R.*

Pyocyanin restricts social cheating in Pseudomonas aeruginosa.

Front. Microbiol. 9:1348 (2018)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Quorum sensing (QS) in Pseudomonas aeruginosa coordinates the expression of virulence factors, such as exoproteases and siderophores, that are public goods utilized by the whole population of bacteria, regardless of whether they invested or not in their production. These public goods can be used by QS defective mutants for growth, and since these mutants do not contribute to public goods production, they are considered social cheaters. Pyocyanin is a phenazine that is a toxic, QS-controlled metabolite produced by P. aeruginosa. It is a redox-active compound and promotes the generation of reactive oxygen species; it also possesses antibacterial properties and increases fitness in competition with other bacterial species. Since QS-deficient individuals are less able to tolerate oxidative stress, we hypothesized that the pyocyanin produced by the wild-type population could promote selection of functional QS systems in this bacterium. Here, we demonstrate, using competition experiments and mathematical models, that, indeed, pyocyanin increases the fitness of the cooperative QS-proficient individuals and restricts the appearance of social cheaters. In addition, we also show that pyocyanin is able to select QS in other bacteria such as Acinetobacter baumannii.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Public Goods ; Pyocyanin ; Social Cheating ; Quorum Sensing (os) ; Oxidative Stress ; Policing; Polycyclic Aromatic-hydrocarbons; Lung Epithelial-cells; Yangtze-river Delta; 6 European Cities; Ambient Air; Oxidative Stress; Mouse Lung; A549 Cells; Cytotoxic Responses; Seasonal-variation
Sprache
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1664-302X
e-ISSN 1664-302X
Zeitschrift Frontiers in Microbiology
Quellenangaben Band: 9, Heft: , Seiten: , Artikelnummer: 1348 Supplement: ,
Verlag Frontiers
Verlagsort Po Box 211, 1000 Ae Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503800-001
DOI 10.3389/fmicb.2018.01348
WOS ID WOS:000436453800002
Scopus ID 85049060989
Erfassungsdatum 2018-07-10
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