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Thiele, I. ; Linseisen, J. ; Heier, M. ; Holle, R. ; Kirchberger, I.* ; Peters, A. ; Thorand, B. ; Meisinger, C.

Time trends in stroke incidence and in prevalence of risk factors in Southern Germany, 1989 to 2008/09.

Sci. Rep. 8:11981 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In prior studies, stroke incidence has mainly shown either declining time trends or stable rates in high-income countries. Changes could partially be linked to trends in classic cardiovascular disease (CVD) risk factors. In the present study, we analyzed the incidence of stroke in parallel with the prevalence of CVD risk factors over time in a German population. Data from three independent population-based MONICA/KORA Augsburg surveys conducted in 1989/90 (S2), 1994/95 (S3), and 1999/2001 (S4) were used to calculate age-standardized incidence rates (IR) of first-ever stroke over eight years from each baseline survey. Furthermore, the age-standardized prevalence rates of CVD risk factors were analyzed for these surveys. Changes in IR or prevalence were considered significantly different if their 95% confidence intervals (CI) did not overlap. The age-standardized IR of stroke showed no significant time trend (S2: IR = 203.4 per 100,000 person-years; CI 176.4-233.4, S3: IR = 225.6; 197.1-257.0, S4: IR = 209.9; CI 182.4-240.3). In agreement, the prevalence of the CVD risk factors was quite stable over time, showing divergent, but mostly non-significant changes. However, due to the aging Western societies and the longer survival time of stroke patients, the total number of stroke patients in the population will increase even with a stable IR.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Global Burden; Case-fatality; Hemorrhagic Stroke; Incidence Rates; Monica Project; Late 20th-century; Regional Burden; Ischemic-stroke; Mortality; Sweden
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 8, Heft: 1, Seiten: , Artikelnummer: 11981 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Independent Research Group Clinical Epidemiology (KEPI)
Institute of Health Economics and Health Care Management (IGM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-006
G-504000-010
G-502900-001
G-504090-001
G-505300-002
G-504000-002
DOI 10.1038/s41598-018-30350-8
WOS ID WOS:000441300700025
Scopus ID 85051520115
PubMed ID 30097633
Erfassungsdatum 2018-09-05
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