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Kestenbaum, B.* ; Glazer, N.L.* ; Köttgen, A.* ; Felix, J.F.* ; Hwang, S.J.* ; Liu, Y.M.* ; Lohman, K.* ; Kritchevsky, S.B.* ; Hausman, D.B.* ; Petersen, A.-K. ; Gieger, C. ; Ried, J.S. ; Meitinger, T. ; Strom, T.M. ; Wichmann, H.-E. ; Campbell, H.* ; Hayward, C.* ; Rudan, I.* ; de Boer, I.H.* ; Psaty, B.M.* ; Rice, K.M.* ; Chen, Y.D.I.* ; Li, M.* ; Arking, D.E.* ; Boerwinkle, E.* ; Coresh, J.* ; Yang, Q.O.* ; Levy, D.* ; van Rooij, F.J.A.* ; Dehghan, A.* ; Rivadeneira, F.* ; Uitterlinden, A.G.* ; Hofman, A.* ; van Duijn, C.M.* ; Shlipak, M.G.* ; Kao, W.H.L.* ; Witteman, J.C.M.* ; Siscovick, D.S.* ; Fox, C.S.*

Common genetic variants associate with serum phosphorus concentration.

J. Am. Soc. Nephrol. 21, 1223-1232 (2010)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations, genetic variation may determine interindividual variation in phosphorus metabolism. Here, we report a comprehensive genome-wide association study of serum phosphorus concentration. We evaluated 16,264 participants of European ancestry from the Cardiovascular Heath Study, Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and the Rotterdam Study. We excluded participants with an estimated GFR <45 ml/min per 1.73 m(2) to focus on phosphorus metabolism under normal conditions. We imputed genotypes to approximately 2.5 million single-nucleotide polymorphisms in the HapMap and combined study-specific findings using meta-analysis. We tested top polymorphisms from discovery cohorts in a 5444-person replication sample. Polymorphisms in seven loci with minor allele frequencies 0.08 to 0.49 associate with serum phosphorus concentration (P = 3.5 x 10(-16) to 3.6 x 10(-7)). Three loci were near genes encoding the kidney-specific type IIa sodium phosphate co-transporter (SLC34A1), the calcium-sensing receptor (CASR), and fibroblast growth factor 23 (FGF23), proteins that contribute to phosphorus metabolism. We also identified genes encoding phosphatases, kinases, and phosphodiesterases that have yet-undetermined roles in phosphorus homeostasis. In the replication sample, five of seven top polymorphisms associate with serum phosphorous concentrations (P < 0.05 for each). In conclusion, common genetic variants associate with serum phosphorus in the general population. Further study of the loci identified in this study may help elucidate mechanisms of phosphorus regulation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dominant hypophosphatemic rickets; Fibroblast growth factor-23; Genome-wide association; vitamin-D; Phosphate regulation; Mortality risk; Disease; Calcification; Mechanisms; Mutations
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 1046-6673
e-ISSN 1533-3450
Zeitschrift Journal of the American Society of Nephrology
Quellenangaben Band: 21, Heft: 7, Seiten: 1223-1232 Artikelnummer: , Supplement: ,
Verlag American Society of Nephrology
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-500700-001
PubMed ID 20558539
DOI 10.1681/ASN.2009111104
Erfassungsdatum 2010-10-13
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