PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Rotter, M. ; Brandmaier, S. ; Covic, M. ; Burek, K.* ; Hertel, J.* ; Troll, M. ; Bader, E. ; Adam, J. ; Prehn, C. ; Rathkolb, B. ; Hrabě de Angelis, M. ; Grabe, H.J.* ; Daniel, H.* ; Kantermann, T.* ; Harth, V.* ; Illig, T.* ; Pallapies, D.* ; Behrens, T.* ; Brüning, T.* ; Adamski, J. ; Lickert, H. ; Rabstein, S.* ; Wang-Sattler, R.

Night shift work affects urine metabolite profiles of nurses with early chronotype.

Metabolites 8:45 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Night shift work can have a serious impact on health. Here, we assess whether and how night shift work influences the metabolite profiles, specifically with respect to different chronotype classes. We have recruited 100 women including 68 nurses working both, day shift and night shifts for up to 5 consecutive days and collected 3640 spontaneous urine samples. About 424 waking-up urine samples were measured using a targeted metabolomics approach. To account for urine dilution, we applied three methods to normalize the metabolite values: creatinine-, osmolality- and regression-based normalization. Based on linear mixed effect models, we found 31 metabolites significantly (false discovery rate <0.05) affected in nurses working in night shifts. One metabolite, acylcarnitine C10:2, was consistently identified with all three normalization methods. We further observed 11 and 4 metabolites significantly associated with night shift in early and late chronotype classes, respectively. Increased levels of medium- and long chain acylcarnitines indicate a strong impairment of the fatty acid oxidation. Our results show that night shift work influences acylcarnitines and BCAAs, particularly in nurses in the early chronotype class. Women with intermediate and late chronotypes appear to be less affected by night shift work.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
0.000
0.925
6
9
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Metabolomics ; Urine Normalization ; Women's' Health ; Night Shift Work ; Chronotypes; Circadian Clock; Amino-acids; Sleep; Acylcarnitines; Questionnaire; Creatinine; Melatonin; Quality; Cancer; Normalization
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Zeitschrift Metabolites
Quellenangaben Band: 8, Heft: 3, Seiten: , Artikelnummer: 45 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Diabetes and Regeneration Research (IDR)
Research Unit Genome Analysis Center (IEG-GAC)
Institute of Experimental Genetics (IEG)
Institute of Stem Cell Research (ISF)
POF Topic(s) 30202 - Environmental Health
90000 - German Center for Diabetes Research

30201 - Metabolic Health
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
Helmholtz Diabetes Center

Stem Cell and Neuroscience
PSP-Element(e) G-504091-003
G-504091-001
G-504091-002
G-501900-234
G-504091-004
A-630440-001
G-500692-001
G-500600-001
G-502300-001
G-501900-402
G-500800-001
DOI 10.3390/metabo8030045
WOS ID WOS:000445152200006
Scopus ID 85053073234
PubMed ID 30134533
Erfassungsdatum 2018-09-05
[➜Korrektur melden]