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Trenkwalder, C.* ; Allen, R.J.* ; Högl, B.* ; Clemens, S.* ; Patton, S.* ; Schormair, B. ; Winkelmann, J.

Comorbidities, treatment, and pathophysiology in restless legs syndrome.

Lancet Neurol. 17, 994-1005 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological condition whose manifestation is affected by complex environmental and genetic interactions. Restless legs syndrome can occur on its own, mostly at a young age, or with comorbidities such as cardiovascular disease, diabetes, and arterial hypertension, making it a difficult condition to properly diagnose. However, the concept of restless legs syndrome as being two entities, primary or secondary to another condition, has been challenged with genetic data providing further insight into the pathophysiology of the condition. Although dopaminergic treatment was formerly the first-line therapy, prolonged use can result in a serious worsening of symptoms known as augmentation. Clinical studies on pregabalin, gabapentin enacarbil, oxycodone-naloxone, and iron preparations have provided new treatment options, but most patients still report inadequate long-term management of symptoms. Studies of the hypoxic pathway activation and iron deficiency have provided valuable information about the pathophysiology of restless legs syndrome that should now be translated into new, more effective treatments for restless legs syndrome.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Genome-wide Association; Willis-ekbom Disease; Periodic Limb Movements; Iron-deficiency Anemia; Open-label Extension; Stage Renal-disease; Genetic Risk-factor; Parkinsons-disease; Task-force; Diagnostic-criteria
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1474-4422
e-ISSN 1474-4422
Zeitschrift Lancet Neurology, The
Quellenangaben Band: 17, Heft: 11, Seiten: 994-1005 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 360 Park Ave South, New York, Ny 10010-1710 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Neurogenomics (ING)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503200-001
DOI 10.1016/S1474-4422(18)30311-9
WOS ID WOS:000447637500012
Scopus ID 85055027632
PubMed ID 30244828
Erfassungsdatum 2018-10-02
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