Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The emerging role of EpCAM in cancer and stem cell signaling.
Cancer Res. 69, 5627-5629 (2009)
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
7.543
2.720
207
400
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
colorectal-carcinoma; adhesion molecule; breast-cancer; antigen epcam; ep-cam; cadherins; invasion; marker
Sprache
englisch
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
2010
ISSN (print) / ISBN
0008-5472
e-ISSN
1538-7445
Zeitschrift
Cancer Research
Quellenangaben
Band: 69,
Heft: 14,
Seiten: 5627-5629
Verlag
American Association for Cancer Research (AACR)
Verlagsort
Philadelphia, Pa.
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Molecular Oncology (AGV-KON)
PSP-Element(e)
G-520700-001
PubMed ID
19584271
Erfassungsdatum
2009-12-31