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Bartsch, D.K.* ; Gercke, N.* ; Strauch, K. ; Wieboldt, R.* ; Matthäi, E.* ; Wagner, V.* ; Rospleszcz, S ; Schäfer, A.S.* ; Franke, F.S.* ; Mintziras, I.* ; Bauer, C.* ; Grote, T.* ; Figiel, J.* ; Di Fazio, P.* ; Burchert, A.* ; Reinartz, S.* ; Pogge von Strandmann, E.* ; Klöppel, G.* ; Slater, E.P.*

The Combination of MiRNA-196b, LCN2, and TIMP1 is a potential set of circulating biomarkers for screening individuals at risk for familial pancreatic cancer.

J. Clin. Med. 7:295 (2018)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Individuals at risk (IAR) of familial pancreatic cancer (FPC) are good candidates for screening. Unfortunately, neither reliable imaging modalities nor biomarkers are available to detect high-grade precursor lesions or early cancer. Circulating levels of candidate biomarkers LCN2, TIMP1, Glypican-1, RNU2-1f, and miRNA-196b were analyzed in 218 individuals with sporadic pancreatic ductal adenocarcinoma (PDAC, n = 50), FPC (n = 20), chronic pancreatitis (n = 10), IAR with relevant precursor lesions (n = 11) or non-relevant lesions (n = 5), 20 controls, and IAR with (n = 51) or without (n = 51) lesions on pancreatic imaging. In addition, corresponding duodenal juice samples were analyzed for Glypican-1 (n = 144) enrichment and KRAS mutations (n = 123). The panel miR-196b/LCN2/TIMP1 could distinguish high-grade lesions and stage I PDAC from controls with absolute specificity and sensitivity. In contrast, Glypican-1 enrichment in serum exosomes and duodenal juice was not diagnostic. KRAS mutations in duodenal juice were detected in 9 of 12 patients with PDAC and only 4 of 9 IAR with relevant precursor lesions. IAR with lesions on imaging had elevated miR-196b/LCN2/TIMP1 levels (p = 0.0007) and KRAS mutations in duodenal juice (p = 0.0004) significantly more often than IAR without imaging lesions. The combination miR-196b/LCN2/TIMP1 might be a promising biomarker set for the detection of high-grade PDAC precursor lesions in IAR of FPC families.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Pancreatic Ductal Adenocarcinoma ; Lcn2 ; Ngal ; Timp1 ; Glypican-1 ; Mirna-196b ; Kras Mutation; Gelatinase-associated Lipocalin; Intraepithelial Neoplasia; Diagnostic Biomarker; Microrna; Adenocarcinoma; Validation; Exosomes; Marker; Ngal
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2077-0383
e-ISSN 2077-0383
Zeitschrift Journal of Clinical Medicine
Quellenangaben Band: 7, Heft: 10, Seiten: , Artikelnummer: 295 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
DOI 10.3390/jcm7100295
WOS ID WOS:000448819000003
PubMed ID 30241369
Erfassungsdatum 2018-10-29
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