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Macsali, F.* ; Real, F.G.* ; Plana, E.* ; Sunyer, J.* ; Anto, J.* ; Dratva, J.* ; Janson, C.* ; Jarvis, D.* ; Omenaas, E.R.* ; Zemp, E.* ; Wjst, M. ; Leynaert, B.* ; Svanes, C.*

Early age of menarche, lung function and adult asthma.

Am. J. Respir. Crit. Care Med. 183, 8-14 (2011)

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RATIONALE: Hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes and breast cancer. OBJECTIVES: This study investigates whether age of menarche was related to adult lung function and asthma. MEASUREMENTS: Among participants in the European Community Respiratory Health Survey II, 3354 women aged 27-57 years from random population samples in 21 centers responded to a questionnaire concerning women's health (1998-2002). 2873 had lung function measurements, 2136 measurements of bronchial hyper reactivity (BHR) and 2743 IgE measurements. Logistic, linear and negative binomial regression analyses included adjustment for age, height, body mass index, education, smoking, family size and centre. MAIN RESULTS: Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were lower and asthma more common in women with early menarche. Women reporting menarche

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