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Asami, S.* ; Kallies, W.* ; Guenther, J.C.* ; Stavropoulou, M.* ; Glaser, S.J.* ; Sattler, M.

Ultrashort broadband cooperative pulses for multidimensional bio-molecular NMR experiments.

Angew. Chem.-Int. Edit. 57, 14498-14502 (2018)
Postprint DOI PMC
Open Access Green
NMR spectroscopy at ultra-high magnetic fields requires improved radiofrequency (rf) pulses to cover the increased spectral bandwidth. Optimized 90 degrees pulse pairs were introduced as Ramsey-type cooperative (Ram-COOP) pulses for biomolecular NMR applications. The Ram-COOP element provides broadband excitation with enhanced sensitivity and reduced artifacts even at magnetic fields >1.0GHz H-1 Larmor frequency (23T). A pair of 30s Ram-COOP pulses achieves an excitation bandwidth of 100kHz with a maximum rf field of 20kHz, more than three-fold improved compared to excitation by rectangular pulses. Ram-COOP pulses exhibit little offset-dependent phase errors and are robust to rf inhomogeneity. The performance of the Ram-COOP element is experimentally confirmed with heteronuclear multidimensional NMR experiments, applied to proteins and nucleic acids. Ram-COOP provides broadband excitation at low rf field strength suitable for application at current magnetic fields and beyond 23T.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Hmqc ; Cooperative Broadband Excitation Pulses ; High-field Nmr Spectroscopy ; Noesy ; Optimal Control Theory; Adiabatic Pulses; Spectroscopy; Inversion; Limits
Sprache
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1433-7851
e-ISSN 1521-3773
Zeitschrift Angewandte Chemie - Internationale Edition
Quellenangaben Band: 57, Heft: 44, Seiten: 14498-14502 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503000-001
DOI 10.1002/anie.201800220
WOS ID WOS:000448049800014
PubMed ID 29508496
Erfassungsdatum 2018-11-13
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