PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ravikumar, R.* ; Kalbfuß, N.* ; Gendre, D.* ; Steiner, A.* ; Altmann, M. ; Altmann, S. ; Rybak, K.* ; Edelmann, H.* ; Stephan, F.* ; Lampe, M.* ; Facher, E.* ; Wanner, G.* ; Falter-Braun, P. ; Bhalerao, R.P.* ; Assaad, F.F.*

Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis.

Development 145:dev169201 (2018)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
5.413
1.407
16
16
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Tgn ; Echidna ; Trappii ; Network Interactions ; Sorting ; Cytokinesis; Cell-wall Polysaccharides; Secretory Trafficking; Rab Gtpase; Protein; Cytokinesis; Membrane; Trappii; Colocalization; Dynamics; Complex
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Zeitschrift Development / Company of Biologists
Quellenangaben Band: 145, Heft: 21, Seiten: , Artikelnummer: dev169201 Supplement: ,
Verlag Company of Biologists
Verlagsort Bidder Building, Station Rd, Histon, Cambridge Cb24 9lf, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Network Biology (INET)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-506400-001
DOI 10.1242/dev.169201
WOS ID WOS:000451189600017
Scopus ID 85056372716
PubMed ID 30404777
Erfassungsdatum 2018-11-13
[➜Korrektur melden]