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Pagel, P. ; Oesterheld, M. ; Stuempflen, V. ; Frishman, D.

The DIMA web resource-exploring the protein domain network.

Bioinformatics 22, 997-998 (2006)
Verlagsversion Volltext DOI PMC
Open Access Gold
Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length protein chains. In this work we present a comprehensive web resource for exploring the Domain Interaction MAp (DIMA), interactively. The tool aims at integration of multiple data sources and prediction techniques, two of which have been implemented so far: domain phylogenetic profiling and experimentally demonstrated domain contacts from known three-dimensional structures. A powerful yet simple user interface enables the user to compute, visualize, navigate and download domain networks based on specific search criteria.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter DATABASE
Sprache englisch
Veröffentlichungsjahr 2006
HGF-Berichtsjahr 2006
e-ISSN 1367-4811
Zeitschrift Bioinformatics
Quellenangaben Band: 22, Heft: 8, Seiten: 997-998 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503700-001
PubMed ID 16481337
DOI 10.1093/bioinformatics/btl050
WOS ID WOS:000236612900013
Scopus ID 33645818955
Erfassungsdatum 2006-12-18
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