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Wank, M. ; Schilling, D. ; Schmid, T.E. ; Meyer, B.* ; Gempt, J.* ; Barz, M.* ; Schlegel, J.* ; Liesche, F.* ; Kessel, K.A. ; Wiestler, B.* ; Bette, S.* ; Zimmer, C.* ; Combs, S.E.

Human glioma migration and infiltration properties as a target for personalized radiation medicine.

Cancers 10:456 (2018)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Gliomas are primary brain tumors that present the majority of malignant adult brain tumors. Gliomas are subdivided into low- and high-grade tumors. Despite extensive research in recent years, the prognosis of malignant glioma patients remains poor. This is caused by naturally highly infiltrative capacities as well as high levels of radio- and chemoresistance. Additionally, it was shown that low linear energy transfer (LET) irradiation enhances migration and invasion of several glioma entities which might counteract today's treatment concepts. However, this finding is discussed controversially. In the era of personalized medicine, this controversial data might be attributed to the patient-specific heterogeneity that ultimately could be used for treatment. Thus, current developments in glioma therapy should be seen in the context of intrinsic and radiation-enhanced migration and invasion. Due to the natural heterogeneity of glioma cells and different radiation responses, a personalized radiation treatment concept is suggested and alternative radiation concepts are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Primary Brain Tumor ; Migration And Invasion ; Irradiation ; Survival ; Tumor Heterogeneity ; Personalized Medicine ; Brain Metastases ; Radiotherapy ; Treatment Resistance; Central-nervous-system; Glioblastoma-multiforme; Malignant Glioma; Phase-ii; Ionizing-radiation; Ion Irradiation; Cell Migration; Radiotherapy; Invasion; Survival
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2072-6694
Zeitschrift Cancers
Quellenangaben Band: 10, Heft: 11, Seiten: , Artikelnummer: 456 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501300-001
DOI 10.3390/cancers10110456
WOS ID WOS:000451307700063
Scopus ID 85057179460
PubMed ID 30463322
Erfassungsdatum 2018-12-07
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