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Melsbach, A. ; Ponsin, V.* ; Torrentó, C.* ; Lihl, C. ; Hofstetter, T.B.* ; Hunkeler, D.* ; Elsner, M.

13C- and 15N-isotope analysis of desphenylchloridazon by Liquid chromatography-isotope-ratio mass spectrometry and derivatization gas chromatography-isotope-ratio mass spectrometry.

Anal. Chem. 91, 3412-3420 (2019)
Postprint Forschungsdaten DOI PMC
Open Access Green
The widespread application of herbicides impacts surface water and groundwater. Metabolites (e.g., desphenylchloridazon from chloridazon) may be persistent and even more polar than the parent herbicide, which increases the risk of groundwater contamination. When parent herbicides are still applied, metabolites are constantly formed and may also be degraded. Evaluating their degradation on the basis of concentration measurements is, therefore, difficult. This study presents compound-specific stable isotope analysis (CSIA) of nitrogen- and carbon-isotope ratios at natural abundances as an alternative analytical approach to track the origin, formation, and degradation of desphenylchloridazon (DPC), the major degradation product of the herbicide chloridazon. Methods were developed and validated for carbon- and nitrogen-isotope analysis (delta C-13 and delta N-15) of DPC by liquid chromatography-isotope-ratio mass spectrometry (LC-IRMS) and derivatization gas chromatography-IRMS (GC-IRMS), respectively. Injecting standards directly onto an Atlantis LC-column resulted in reproducible delta(13)-isotope analysis (standard deviation <0.5 parts per thousand) by LC-IRMS with a limit of precise analysis of 996 ng of DPC on-column. Accurate and reproducible delta N-15 analysis with a standard deviation of <0.4 parts per thousand was achieved by GC-IRMS after derivatization of >100 ng of DPC with 160-fold excess of (trimethylsilyl)diazomethane. Application of the method to environmental-seepage water indicated that newly formed DPC could be distinguished from "old" DPC by the different isotopic signatures of the two DPC sources.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Compound-specific Carbon; Pesticide Degradation; Organic-compounds; Contaminants; Groundwater; Water; Trimethylsilyldiazomethane; Fractionation; Methylation; Metabolites
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0003-2700
e-ISSN 1520-6882
Zeitschrift Analytical Chemistry
Quellenangaben Band: 91, Heft: 5, Seiten: 3412-3420 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Verlagsort 1155 16th St, Nw, Washington, Dc 20036 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Groundwater Ecology (IGOE)
POF Topic(s) 20403 - Sustainable Water Management
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504390-001
DOI 10.1021/acs.analchem.8b04906
WOS ID WOS:000460709200034
Scopus ID 85062071927
PubMed ID 30672693
Erfassungsdatum 2019-03-18
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