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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ubiquitin ligases in cancer immunotherapy - balancing antitumor and autoimmunity.
Trends Mol. Med. 25, 428-443 (2019)
Considerable progress has been made in understanding the contribution of E3 ubiquitin ligases to health and disease, including the pathogenesis of immunological disorders. Ubiquitin ligases exert exquisite spatial and temporal control over protein stability and function, and are thus crucial for the regulation of both innate and adaptive immunity. Given that immune responses can be both detrimental (autoimmunity) and beneficial (antitumor immunity), it is vital to understand how ubiquitin ligases maintain immunological homeostasis. Such knowledge could reveal novel mechanisms underlying immune regulation and identify new therapeutic approaches to enhance antitumor immunity and safeguard against autoimmunity.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
11.028
2.395
19
18
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
E3 Ubiquitin Ligase ; Antitumor Immunity ; Autoimmunity ; Immune Checkpoint; Regulatory T-cells; Nf-kappa-b; Cbl-b; Molecular-mechanisms; Adverse Events; Negative Regulator; Melanoma Patients; Adoptive Therapy; Messenger-rnas; Self-tolerance
Sprache
Veröffentlichungsjahr
2019
HGF-Berichtsjahr
2019
ISSN (print) / ISBN
1471-4914
e-ISSN
1471-499X
Zeitschrift
Trends in Molecular Medicine
Quellenangaben
Band: 25,
Heft: 5,
Seiten: 428-443
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-506600-001
WOS ID
WOS:000465560500007
Scopus ID
85062914792
PubMed ID
30898473
Erfassungsdatum
2019-04-01