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Menditto, E.* ; Costa, E.* ; Midao, L.* ; Bosnic-Anticevich, S.* ; Novellino, E.* ; Bialek, S.* ; Briedis, V.* ; Mair, A.* ; Rajabian-Soderlund, R.* ; Arnavielhe, S.* ; Bedbrook, A.* ; Czarlewski, W.* ; Annesi-Maesano, I.* ; Antò, J.M.* ; Devillier, P.* ; De Vries, G.* ; Keil, T.* ; Sheikh, A.* ; Orlando, V.* ; Larenas-Linnemann, D.* ; Cecchi, L.* ; De Feo, G.* ; Illario, M.* ; Stellato, C.* ; Fonseca, J.* ; Malva, J.* ; Morais-Almeida, M.* ; Pereira, A.M.* ; Todo-Bom, A.M.* ; Kvedariene, V.* ; Valiulis, A.* ; Bergmann, K.C.* ; Klimek, L.* ; Moesges, R.* ; Pfaar, O.* ; Zuberbier, T.* ; Cardona, V.* ; Mullol, J.* ; Papadopoulos, N.G.* ; Prokopakis, E.P.* ; Bewick, M.* ; Ryan, D.* ; Roller-Wirnsberger, R.E.* ; Tomazic, P.V.* ; Cruz, A.A.* ; Kuna, P.* ; Samolinski, B.* ; Fokkens, W.J.* ; Reitsma, S.* ; Bosse, I.* ; Fontaine, J.-F.* ; Laune, D.* ; Haahtela, T.* ; Toppila-Salmi, S.* ; Bachert, C.* ; Hellings, P.W.* ; Melén, E.* ; Wickman, M.* ; Bindslev-Jensen, C.* ; Eller, E.* ; O'Hehir, R.E.* ; Cingi, C.* ; Gemicioğlu, B.* ; Kalayci, O.* ; Ivancevich, J.C.* ; Bousquet, J.* ; MASK Study Group (Darsow, U.)

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study.

Clin. Exp. Allergy 49, 442-460 (2019)

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Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App.Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach.Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users.Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.

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