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Shah, N. ; Decker, T.-M. ; Eick, D.

Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells.

Biol. Lett. 15:20190068 (2019)
Verlagsversion DOI PMC
Open Access Hybrid
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The carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) consists of 26 and 52 heptad-repeats in yeast and mammals, respectively. Studies in yeast showed that the strong periodicity of the YSPTSPS heptads is dispensable for cell growth and that di-heptads interspersed by spacers can act as minimal functional units (MFUs) to fulfil all essential CTD functions. Here, we show that the MFU of mammalian cells is significantly larger than in yeast and consists of penta-heptads. We further show that the distance between two MFUs is critical for the functions of mammalian CTD. Our study suggests that the general structure of the CTD remained largely unchanged in yeast and mammals; however, besides the number of heptad-repeats, also the length of the MFU significantly increased in mammals.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rna Polymerase Ii (pol Ii) ; C-terminal Domain (ctd) ; Heptad-repeats ; Low-complexity Domain ; Minimal Functional Unit (mfu); Carboxyl-terminal Domain; Largest Subunit; Integrator Complex; Phosphorylation; Transcription; Mediator; Repeat; Code
Sprache
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1744-9561
e-ISSN 1744-957X
Zeitschrift Biology letters
Quellenangaben Band: 15, Heft: 5, Seiten: , Artikelnummer: 20190068 Supplement: ,
Verlag Royal Society of Chemistry (RSC)
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Functional Epigenetics (IFE)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502890-001
DOI 10.1098/rsbl.2019.0068
WOS ID WOS:000470116400008
Scopus ID 85066275133
PubMed ID 31088280
Erfassungsdatum 2019-05-17
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