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Kimm, M.A.* ; Gross, C.* ; Déan-Ben, X.L.* ; Ron, A. ; Rummeny, E.J.* ; Lin, H.-C. ; Höltke, C.* ; Razansky, D. ; Wildgruber, M.*

Optoacoustic properties of Doxorubicin - A pilot study.

PLoS ONE 14:e0217576 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. We therefore aimed to further investigate the optoacoustic properties of DOX in biological tissue in order to explore its potential as theranostic agent. We analysed doxorubicin hydrochloride (Dox center dot HCl) and liposomal encapsulated doxorubicin hydrochloride (Dox center dot Lipo), two common drugs for anticancer treatment in clinical medicine. Optoacoustic measurements revealed a strong signal of both doxorubicin substrates at 488 nm excitation wavelength. Post mortem analysis of intra-tumoral injections of DOX revealed a detectable optoacoustic signal even at three days after the injection. We thereby demonstrate the general feasibility of doxorubicin detection in biological tissue by means of optoacoustic tomography, which could be applied for high resolution imaging at mesoscopic depths dictated by effective penetration of visible light into the biological tissues.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Tomography Msot; Tumor; Model; Quantification; Chemotherapy; Liposomes; Dynamics; Cancer; Tissue; Light
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 14, Heft: 5, Seiten: , Artikelnummer: e0217576 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505590-001
DOI 10.1371/journal.pone.0217576
WOS ID WOS:000469759100068
Scopus ID 85066505089
PubMed ID 31150471
Erfassungsdatum 2019-06-05
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