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Wang, X.D.* ; Rammes, G.* ; Kraev, I.* ; Wolf, M.* ; Liebl, C.* ; Scharf, S.H.* ; Rice, C.J.* ; Wurst, W. ; Holsboer, F.* ; Deussing, J.M.* ; Baram, T.Z.* ; Stewart, M.G.* ; Müller, M.B.* ; Schmidt, M.V.*

Forebrain CRF1 modulates early-life stress-programmed cognitive deficits.

J. Neurosci. 31, 13625-13634 (2011)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Childhood traumatic events hamper the development of the hippocampus and impair declarative memory in susceptible individuals. Persistent elevations of hippocampal corticotropin-releasing factor (CRF), acting through CRF receptor 1 (CRF₁), in experimental models of early-life stress have suggested a role for this endogenous stress hormone in the resulting structural modifications and cognitive dysfunction. However, direct testing of this possibility has been difficult. In the current study, we subjected conditional forebrain CRF₁ knock-out (CRF₁-CKO) mice to an impoverished postnatal environment and examined the role of forebrain CRF₁ in the long-lasting effects of early-life stress on learning and memory. Early-life stress impaired spatial learning and memory in wild-type mice, and postnatal forebrain CRF overexpression reproduced these deleterious effects. Cognitive deficits in stressed wild-type mice were associated with disrupted long-term potentiation (LTP) and a reduced number of dendritic spines in area CA3 but not in CA1. Forebrain CRF₁ deficiency restored cognitive function, LTP and spine density in area CA3, and augmented CA1 LTP and spine density in stressed mice. In addition, early-life stress differentially regulated the amount of hippocampal excitatory and inhibitory synapses in wild-type and CRF₁-CKO mice, accompanied by alterations in the neurexin-neuroligin complex. These data suggest that the functional, structural and molecular changes evoked by early-life stress are at least partly dependent on persistent forebrain CRF₁ signaling, providing a molecular target for the prevention of cognitive deficits in adults with a history of early-life adversity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Corticotropin-releasing hormone; Chronic social stress; Neonatal dexamethasone treatment; Hippocampal synaptic plasticity; Molecular; Molecular-mechanisms; Maternal separation; Spatial memory; Long-term; Receptor; Behavior
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Zeitschrift Journal of Neuroscience
Quellenangaben Band: 31, Heft: 38, Seiten: 13625-13634 Artikelnummer: , Supplement: ,
Verlag Society for Neuroscience
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-001
G-520600-001
G-500500-003
PubMed ID 21940453
DOI 10.1523/JNEUROSCI.2259-11.2011
Scopus ID 80053035683
Erfassungsdatum 2011-11-30
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