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J. Am. Chem. Soc. 141, 12475-12480 (2019)
Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means to transform stable, near-infrared (NJR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivo with 980 nm excitation.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
14.695
2.634
53
85
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Drug-delivery; Quantum Dots; Fluorescence; Nanomachines; Nanospheres; Absorption; Principles; Stimuli; Design
Sprache
englisch
Veröffentlichungsjahr
2019
HGF-Berichtsjahr
2019
ISSN (print) / ISBN
0002-7863
e-ISSN
1520-5126
Zeitschrift
Journal of the American Chemical Society
Quellenangaben
Band: 141,
Heft: 32,
Seiten: 12475-12480
Verlag
American Chemical Society (ACS)
Verlagsort
1155 16th St, Nw, Washington, Dc 20036 Usa
Begutachtungsstatus
Peer reviewed
Institut(e)
Helmholtz Pioneer Campus (HPC)
POF Topic(s)
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Pioneer Campus
PSP-Element(e)
G-510001-001
WOS ID
WOS:000481563500008
Scopus ID
85070666967
PubMed ID
31353894
Erfassungsdatum
2019-08-06