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Stemmer, K. ; Müller, T.D. ; DiMarchi, R.D.* ; Pfluger, P.T. ; Tschöp, M.H.

CNS-targeting pharmacological interventions for the metabolic syndrome.

J. Clin. Invest. 130, 4058-4071 (2019)
Verlagsversion Preprint Forschungsdaten DOI PMC
Open Access Gold
The metabolic syndrome (MetS) encompasses medical conditions such as obesity, hyperglycemia, high blood pressure, and dyslipidemia that are major drivers for the ever-increasing prevalence of type 2 diabetes, cardiovascular diseases, and certain types of cancer. At the core of clinical strategies against the MetS is weight loss, induced by bariatric surgery, lifestyle changes based on calorie reduction and exercise, or pharmacology. This Review summarizes the past, current, and future efforts of targeting the MetS by pharmacological agents. Major emphasis is given to drugs that target the CNS as a key denominator for obesity and its comorbid sequelae.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Glucagon-like Peptide-1; Controlled-release Phentermine/topiramate; Dependent Insulinotropic Peptide; Cannabinoid-1 Receptor Blocker; Melanin-concentrating Hormone; Neurons Regulate Energy; Once-daily Liraglutide; Diet-induced Obesity; Food-intake; Weight-loss
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0021-9738
e-ISSN 1558-8238
Zeitschrift Journal of Clinical Investigation
Quellenangaben Band: 130, Heft: 10, Seiten: 4058-4071 Artikelnummer: , Supplement: ,
Verlag American Society of Clinical Investigation
Verlagsort 2015 Manchester Rd, Ann Arbor, Mi 48104 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-221
G-502294-001
DOI 10.1172/JCI129195
WOS ID WOS:000488537800014
Scopus ID 85071171615
PubMed ID 31380808
Erfassungsdatum 2019-08-14
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