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Ragazzini, R.* ; Pérez-Palacios, R.* ; Baymaz, I.H.* ; Diop, S.* ; Ancelin, K.* ; Zielinski, D.* ; Michaud, A.* ; Givelet, M.* ; Borsos, M. ; Aflaki, S.* ; Legoix, P.* ; Jansen, P.W.T.C.* ; Servant, N.* ; Torres-Padilla, M.E. ; Bourc'his, D.* ; Fouchet, P.* ; Vermeulen, M.* ; Margueron, R.*

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

Nat. Commun. 10:3858 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The Polycomb group of proteins is required for the proper orchestration of gene expression due to its role in maintaining transcriptional silencing. It is composed of several chromatin modifying complexes, including Polycomb Repressive Complex 2 (PRC2), which deposits H3K27me2/3. Here, we report the identification of a cofactor of PRC2, EZHIP (EZH1/2 Inhibitory Protein), expressed predominantly in the gonads. EZHIP limits the enzymatic activity of PRC2 and lessens the interaction between the core complex and its accessory subunits, but does not interfere with PRC2 recruitment to chromatin. Deletion of Ezhip in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but is associated with a reduction of follicles in aging. Our results suggest that mature oocytes Ezhip-/- might not be fully functional and indicate that fertility is strongly impaired in Ezhip-/- females. Altogether, our study uncovers EZHIP as a regulator of chromatin landscape in gametes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Embryonic Stem-cells; Chromatin Dynamics; Prc2; Mouse; Methylation; Protein; Transcriptome; Reveals; Aebp2; Dna
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 10, Heft: 1, Seiten: , Artikelnummer: 3858 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
DOI 10.1038/s41467-019-11800-x
WOS ID WOS:000482567200006
Scopus ID 85071152287
PubMed ID 31451685
Erfassungsdatum 2019-09-19
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