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Couto Alves, A.* ; De Silva, N.M.G.* ; Karhunen, V.* ; Sovio, U.* ; Das, S.* ; Rob Taal, H.* ; Warrington, N.M.* ; Lewin, A.M.* ; Kaakinen, M.* ; Cousminer, D.L.* ; Thiering, E. ; Timpson, N.J.* ; Bond, T.A.* ; Lowry, E.* ; Brown, C.D.* ; Lindi, V.* ; Bradfield, J.P.* ; Geller, F.* ; Speed, D.* ; Coin, L.J.M.* ; Loh, M.* ; Barton, S.J.* ; Beilin, L.J.* ; Bisgaard, H.* ; Bønnelykke, K.* ; Alili, R.* ; Hatoum, I.J.* ; Schramm, K. ; Cartwright, R.* ; Charles, M.A.* ; Salerno, V.* ; Clément, K.* ; Claringbould, A.A.J.* ; van Duijn, C.M.* ; Moltchanova, E.* ; Eriksson, J.G.* ; Elks, C.* ; Feenstra, B.* ; Flexeder, C. ; Franks, S.* ; Frayling, T.M.* ; Freathy, R.M.* ; Elliott, P.* ; Widén, E.* ; Hakonarson, H.* ; Hattersley, A.T.* ; Rodriguez, A.* ; Banterle, M.* ; Heinrich, J. ; Heude, B.* ; Holloway, J.W.* ; Hofman, A.* ; Hyppönen, E.* ; Inskip, H.* ; Kaplan, L.M.* ; Hedman, A.K.* ; Läärä, E.* ; Prokisch, H. ; Grallert, H. ; Lakka, T.A.* ; Lawlor, D.A.* ; Melbye, M.* ; Ahluwalia, T.S.* ; Marinelli, M.* ; Millwood, I.Y.* ; Palmer, L.J.* ; Pennell, C.E.* ; Perry, J.R.* ; Ring, S.M.* ; Savolainen, M.J.* ; Rivadeneira, F.* ; Standl, M. ; Sunyer, J.* ; Tiesler, C.M. ; Uitterlinden, A.G.* ; Schierding, W.* ; Sullivan, O.M.* ; Prokopenko, I.* ; Herzig, K.H.* ; Smith, G.D.* ; O'Reilly, P.* ; Felix, J.F.* ; Buxton, J.L.* ; Blakemore, A.I.F.* ; Ong, K.K.* ; Jaddoe, V.W.V.* ; Grant, S.F.A.* ; Sebert, S.* ; McCarthy, M.I.*

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Sci. Adv. 5:eaaw3095 (2019)
Verlagsversion Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Body-mass Index; Genome-wide Association; Blood-pressure; Early-life; Metabolic Risk; Birth Cohort; Fto Gene; Adiposity; Obesity; Age
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 5, Heft: 9, Seiten: , Artikelnummer: eaaw3095 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
POF Topic(s) 30202 - Environmental Health
90000 - German Center for Diabetes Research
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-008
G-504091-002
G-501900-401
G-500700-001
DOI 10.1126/sciadv.aaw3095
WOS ID WOS:000491128800014
Scopus ID 85073762530
PubMed ID 31840077
Erfassungsdatum 2019-11-04
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