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Wang, Y.* ; Wu, H.* ; Zelenin, P.* ; Fontanet, P.* ; Wanderoy, S.* ; Petitpré, C.* ; Comai, G.* ; Bellardita, C.* ; Xue-Franzén, Y.* ; Huettl, R.E. ; Huber, A.B. ; Tajbakhsh, S.* ; Kiehn, O.* ; Ernfors, P.* ; Deliagina, T.G.* ; Lallemend, F.* ; Hadjab, S.*

Muscle-selective RUNX3 dependence of sensorimotor circuit development.

Development 146:dev181750 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The control of all our motor outputs requires constant monitoring by proprioceptive sensory neurons (PSNs) that convey continuous muscle sensory inputs to the spinal motor network. Yet the molecular programs that control the establishment of this sensorimotor circuit remain largely unknown. The transcription factor RUNX3 is essential for the early steps of PSNs differentiation, making it difficult to study its role during later aspects of PSNs specification. Here, we conditionally inactivate Runx3 in PSNs after peripheral innervation and identify that RUNX3 is necessary for maintenance of cell identity of only a subgroup of PSNs, without discernable cell death. RUNX3 also controls the sensorimotor connection between PSNs and motor neurons at limb level, with muscle-by-muscle variable sensitivities to the loss of Runx3 that correlate with levels of RUNX3 in PSNs. Finally, we find that muscles and neurotrophin 3 signaling are necessary for maintenance of RUNX3 expression in PSNs. Hence, a transcriptional regulator that is crucial for specifying a generic PSN type identity after neurogenesis is later regulated by target muscle-derived signals to contribute to the specialized aspects of the sensorimotor connection selectivity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Sensory System ; Sensorimotor Circuit ; Dorsal Root Ganglia ; Neuronal Specification ; Neurotrophins; Sensory Neurons; Synaptic Connections; Motor-neurons; Expression; Axons; Differentiation; Specification; Afferents; Patterns; Absence
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Zeitschrift Development / Company of Biologists
Quellenangaben Band: 146, Heft: 20, Seiten: , Artikelnummer: dev181750 Supplement: ,
Verlag Company of Biologists
Verlagsort Bidder Building, Station Rd, Histon, Cambridge Cb24 9lf, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500592-001
G-500500-001
DOI 10.1242/dev.181750
WOS ID WOS:000493947200036
Scopus ID 85074118017
PubMed ID 31575648
Erfassungsdatum 2019-11-07
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