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Salinno, C. ; Cota, P. ; Bastidas-Ponce, A. ; Tarquis Medina, M. ; Lickert, H. ; Bakhti, M.

β-cell maturation and identity in health and disease.

Int. J. Mol. Sci. 20:5417 (2019)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The exponential increase of patients with diabetes mellitus urges for novel therapeutic strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of insulin-producing beta -cells, in patients with type 1 and type 2 diabetes respectively, put these cells at the center of the disease initiation and progression. Therefore, major efforts have been taken to restore the beta -cell mass by cell-replacement or regeneration approaches. Implementing novel therapies requires deciphering the developmental mechanisms that generate beta -cells and determine the acquisition of their physiological phenotype. In this review, we summarize the current understanding of the mechanisms that coordinate the postnatal maturation of beta -cells and define their functional identity. Furthermore, we discuss different routes by which beta -cells lose their features and functionality in type 1 and 2 diabetic conditions. We then focus on potential mechanisms to restore the functionality of those beta -cell populations that have lost their functional phenotype. Finally, we discuss the recent progress and remaining challenges facing the generation of functional mature beta -cells from stem cells for cell-replacement therapy for diabetes treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Beta-cell ; Maturation ; Postnatal ; Identity ; Dysfunction ; Dedifferentiation ; Transdifferentiation ; Senescence ; Sc-beta-cells ; Diabetes; Insulin-secretion; Pancreas Organogenesis; Transcription Factor; Feedback-control; Alpha-cells; In-vitro; Glucose; Differentiation; Dedifferentiation; Proliferation
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 20, Heft: 21, Seiten: , Artikelnummer: 5417 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Regeneration Research (IDR)
Institute of Stem Cell Research (ISF)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
30204 - Cell Programming and Repair
Forschungsfeld(er) Helmholtz Diabetes Center
Stem Cell and Neuroscience
PSP-Element(e) G-502300-001
G-501900-231
G-500800-001
DOI 10.3390/ijms20215417
WOS ID WOS:000498946100175
Scopus ID 85074332735
PubMed ID 31671683
Erfassungsdatum 2019-11-11
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