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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.
Neuron 68, 682-694 (2010)
Verlagsversion
DOI
PMC
Most neurons in the adult mammalian brain survive for the entire life of an individual. However, it is not known which transcriptional pathways regulate this survival in a healthy brain. Here, we identify a pathway regulating neuronal survival in a highly subtype-specific manner. We show that the transcription factor Pax6 expressed in dopaminergic neurons of the olfactory bulb regulates the survival of these neurons by directly controlling the expression of crystallin αA (CryαA), which blocks apoptosis by inhibition of procaspase-3 activation. Re-expression of CryαA fully rescues survival of Pax6-deficient dopaminergic interneurons in vivo and knockdown of CryαA by shRNA in wild-type mice reduces the number of dopaminergic OB interneurons. Strikingly, Pax6 utilizes different DNA-binding domains for its well-known role in fate specification and this role of regulating the survival of specific neuronal subtypes in the mature, healthy brain.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
13.260
4.650
60
89
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
B-CRYSTALLIN; ADULT NEUROGENESIS; MAMMALIAN TELENCEPHALON; PARKINSONS-DISEASE; CEREBRAL-CORTEX; GENETIC-CONTROL; KNOCKOUT MICE; PAIRED DOMAIN; MUS-MUSCULUS; STEM-CELLS
Sprache
englisch
Veröffentlichungsjahr
2010
HGF-Berichtsjahr
2010
ISSN (print) / ISBN
0896-6273
e-ISSN
1097-4199
Zeitschrift
Neuron
Quellenangaben
Band: 68,
Heft: 4,
Seiten: 682-694
Verlag
Cell Press
Verlagsort
Cambridge, Mass.
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30204 - Cell Programming and Repair
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er)
Stem Cell and Neuroscience
Genetics and Epidemiology
Genetics and Epidemiology
PSP-Element(e)
G-500800-001
G-500700-002
G-550900-001
G-500700-002
G-550900-001
PubMed ID
21092858
Scopus ID
78449311026
Erfassungsdatum
2010-11-30