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Jiang, D. ; Rinkevich, Y.

Scars or regeneration?-Dermal fibroblasts as drivers of diverse skin in wound responses.

Int. J. Mol. Sci. 21:617 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring-regeneration continuum. We discuss fibroblast-centric mechanisms that dictate scarring-regeneration continua with a focus on intercellular and cell-matrix adhesion. Improved understanding of fibroblast lineage-specific mechanisms and how they determine scar severity will ultimately allow for the development of antiscarring therapies and the promotion of tissue regeneration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Scarring ; Fibrosis ; Fibroblasts ; Regeneration ; Adhesion; Hair Follicle Regeneration; Growth-factor Receptor; Tissue Regeneration; Granulation-tissue; Hypertrophic Scars; Hippo Pathway; Factor-beta; Fibrosis; Cells; Expression
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 21, Heft: 2, Seiten: , Artikelnummer: 617 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-554000-001
DOI 10.3390/ijms21020617
WOS ID WOS:000515380000247
Scopus ID 85078255988
PubMed ID PMC7014275
Erfassungsdatum 2020-03-31
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