PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Cross-Disorder Group of the Psychiatric Genomics Consortium (Wichmann, H.-E.)

Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

Cell 179, 1469-1482.e11 (2019)
Verlagsversion Preprint DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.
Impact Factor
Scopus SNIP
Scopus
Cited By
Altmetric
36.216
6.570
334
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Gwas ; Psychiatric Genetics ; Cross-disorder Genetics ; Functional Genomics ; Gene Expression ; Genetic Architecture ; Genetic Correlation ; Neurodevelopment ; Pleiotropy ; Psychiatric Disorders
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Zeitschrift Cell
Quellenangaben Band: 179, Heft: 7, Seiten: 1469-1482.e11 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Translational Genomics (ITG)
POF Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-009
G-506700-001
DOI 10.1016/j.cell.2019.11.020
PubMed ID 31835028
Erfassungsdatum 2020-02-11
[➜Korrektur melden]