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Physiology: Does gut hormone PYY3-36 decrease food intake in rodents?
Nature 430, 1 p following 165; discussion 2 (2004)
Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Letter to the Editor
Sprache
englisch
Veröffentlichungsjahr
2004
HGF-Berichtsjahr
2004
ISSN (print) / ISBN
0028-0836
e-ISSN
1476-4687
Zeitschrift
Nature
Quellenangaben
Band: 430,
Heft: 6996,
Seiten: 1 p following 165; discussion 2
Verlag
Nature Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Obesity (IDO)
PubMed ID
15243972
Erfassungsdatum
2020-02-20