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Wang, X.* ; Lou, N.* ; Eberhardt, A.* ; Yang, Y.* ; Kusk, P.* ; Xu, Q.* ; Förstera, B. ; Peng, S.* ; Shi, M.* ; Ladrón-de-Guevara, A.* ; Delle, C.* ; Sigurdsson, B.* ; Xavier, A.L.R.* ; Ertürk, A. ; Libby, R.T.* ; Chen, L.* ; Thrane, A.S.* ; Nedergaard, M.*

An ocular glymphatic clearance system removes beta-amyloid from the rodent eye.

Sci. Transl. Med. 12:eaaw3210 (2020)
Postprint DOI PMC
Open Access Green
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. beta-amyloid (A beta) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After traversing the lamina barrier, intra-axonal A beta was cleared via the perivenous space and subsequently drained to lymphatic vessels. Light-induced pupil constriction enhanced efflux, whereas atropine or raising intracranial pressure blocked efflux. In two distinct murine models of glaucoma, A. leaked from the eye via defects in the lamina barrier instead of directional axonal efflux. The results suggest that, in rodents, the removal of fluid and metabolites from the intraocular space occurs through a glymphatic pathway that might be impaired in glaucoma.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Optic-nerve Head; Ganglion-cell Degeneration; Intraocular-pressure; Mouse Model; Intracranial-pressure; Lamina-cribrosa; Disc Edema; Glaucoma; Brain; Fluid
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 1946-6234
e-ISSN 1946-6242
Zeitschrift Science Translational Medicine
Quellenangaben Band: 12, Heft: 536, Seiten: , Artikelnummer: eaaw3210 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505800-001
DOI 10.1126/scitranslmed.aaw3210
WOS ID WOS:000521830800001
Scopus ID 85082463850
PubMed ID 32213628
Erfassungsdatum 2020-04-02
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