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Skowronek, M.H.* ; Georgi, A.* ; Jamra, R.A.* ; Schumacher, J.* ; Becker, T.* ; Schmael, C.* ; Paul, T.* ; Deschner, M.* ; Höfels, S.* ; Wulff, M.* ; Schwarz, M.* ; Klopp, N. ; Illig, T. ; Propping, P.* ; Cichon, S.* ; Nöthen, M.M.* ; Schulze, T.G.* ; Rietschel, M.*

No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample.

Psychiatr. Genet. 16, 233-234 (2006)
Verlagsversion DOI
Open Access Gold
Altered glutamatergic neurotransmission is considered a potential etiological factor of schizophrenia (SCZ) and affective disorders. The gene ASCT1 (SLC1A4) coding for a Na-dependent neutral aminoacid transporter is a member of the glutamate transporter superfamily and is located on 2p13-14, a region showing linkage to both SCZ and bipolar disorder (BD). ASCT1 can thus be considered a candidate gene for both disorders. In a German sample, we tested for association between ASCT1 and both SCZ and BD. Allele and haplotype frequencies, however, did not differ between cases and controls. Recent findings on the associations between brainderived neurotrophic factor (BDNF) and SCZ and between G72/G30 and BD suggest that SCZ patients with a history of major depressive episodes (MDE) outside psychotic episodes and BD cases with a history of persecutory delusions constitute genetically distinct subgroups of these disorders. Thus, we hypothesized that restricting case definition to those 95 SCZ individuals with MDE and to those 107 BD patients with a history of persecutory delusions might clarify the relationship between BD, SCZ and ASCT1. However, these stratification approaches did not yield any significant association either. Allele and haplotype frequencies did not differ between cases and controls. Our results do not support an association of the ASCT1 gene with BD or SCZ in the German population.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter ASCT1; bipolar disorder; glutamatergic neurotransmission; schizophrenia; SLC1A4
Sprache
Veröffentlichungsjahr 2006
HGF-Berichtsjahr 2007
ISSN (print) / ISBN 0955-8829
e-ISSN 1473-5873
Zeitschrift Psychiatric Genetics
Quellenangaben Band: 16, Heft: 6, Seiten: 233-234 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-003
DOI 10.1097/01.ypg.0000218621.58009.d1
Scopus ID 33751069596
Erfassungsdatum 2007-08-02
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