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Ziegler, C.G.K.* ; Allon, S.J.* ; Nyquist, S.K.* ; Mbano, I.M.* ; Miao, V.N.* ; Tzouanas, C.N.* ; Cao, Y.* ; Yousif, A.S.* ; Bals, J.* ; Hauser, B.M.* ; Feldman, J.* ; Muus, C.* ; Wadsworth, M.H.* ; Kazer, S.W.* ; Hughes, T.K.* ; Doran, B.* ; Gatter, G.J.* ; Vukovic, M.* ; Taliaferro, F.* ; Mead, B.E.* ; Guo, Z.* ; Wang, J.P.* ; Gras, D.* ; Plaisant, M.* ; Ansari, M. ; Angelidis, I. ; Adler, H. ; Sucre, J.M.S.* ; Taylor, C.J.* ; Lin, B.* ; Waghray, A.* ; Mitsialis, V.* ; Dwyer, D.F.* ; Buchheit, K.M.* ; Boyce, J.A.* ; Barrett, N.A.* ; Laidlaw, T.M.* ; Carroll, S.L.* ; Colonna, L.* ; Tkachev, V.* ; Peterson, C.W.* ; Yu, A.* ; Zheng, H.B.* ; Gideon, H.P.* ; Winchell, C.G.* ; Lin, P.L.* ; Bingle, C.D.* ; Snapper, S.B.* ; Kropski, J.A.* ; Theis, F.J. ; Schiller, H. B. ; Zaragosi, L.E.* ; Barbry, P.* ; Leslie, A.* ; Kiem, H.P.* ; Flynn, J.L.* ; Fortune, S.M.* ; Berger, B.* ; Finberg, R.W.* ; Kean, L.S.* ; Garber, M.* ; Schmidt, A.G.* ; Lingwood, D.* ; Shalek, A.K.* ; Ordovas-Montanes, J.*

SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.

Cell 181, 1016-1035 (2020)
Postprint Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. We identify ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. Strikingly, we discovered that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells and extend our findings to in vivo viral infections. Our data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ace2 ; Covid-19 ; Isg ; Sars-cov-2 ; Human ; Influenza ; Interferon ; Mouse ; Non-human Primate ; Scrna-seq; Angiotensin-converting Enzyme-2; Sars Coronavirus; I Interferons; Functional Receptor; Expression; Infection; Virus; Disease; Proteins; Replication
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0092-8674
e-ISSN 1097-4172
Zeitschrift Cell
Quellenangaben Band: 181, Heft: 5, Seiten: 1016-1035 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) German Center for Lung Research (DZL)
Research Unit Lung Repair and Regeneration (LRR)
Institute of Computational Biology (ICB)
POF Topic(s) 80000 - German Center for Lung Research
30202 - Environmental Health
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Lung Research
Enabling and Novel Technologies
PSP-Element(e) G-501800-810
G-503100-005
G-503800-001
DOI 10.1016/j.cell.2020.04.035
WOS ID WOS:000537399500010
PubMed ID 32413319
Erfassungsdatum 2020-05-20
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