PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Bernath, M.M.* ; Bhattacharyya, S.* ; Nho, K.* ; Barupal, D.K.* ; Fiehn, O.* ; Baillie, R.* ; Risacher, S.L.* ; Arnold, M. ; Jacobson, T.* ; Trojanowski, J.Q.* ; Shaw, L.M.* ; Weiner, M.W.* ; Doraiswamy, P.M.* ; Kaddurah-Daouk, R.* ; Saykin, A.J.*

Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers.

Neurology 94, E2088-E2098 (2020)
Postprint DOI PMC
Open Access Green
ObjectiveTo investigate the association of triglyceride (TG) principal component scores with Alzheimer disease (AD) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (A/T/N/V) biomarkers for AD.MethodsSerum levels of 84 TG species were measured with untargeted lipid profiling of 689 participants from the Alzheimer's Disease Neuroimaging Initiative cohort, including 190 cognitively normal older adults (CN), 339 with mild cognitive impairment (MCI), and 160 with AD. Principal component analysis with factor rotation was used for dimension reduction of TG species. Differences in principal components between diagnostic groups and associations between principal components and AD biomarkers (including CSF, MRI and [F-18]fluorodeoxyglucose-PET) were assessed with a generalized linear model approach. In both cases, the Bonferroni method of adjustment was used to correct for multiple comparisons.ResultsThe 84 TGs yielded 9 principal components, 2 of which, consisting of long-chain, polyunsaturated fatty acid-containing TGs (PUTGs), were significantly associated with MCI and AD. Lower levels of PUTGs were observed in MCI and AD compared to CN. PUTG principal component scores were also significantly associated with hippocampal volume and entorhinal cortical thickness. In participants carrying the APOE epsilon 4 allele, these principal components were significantly associated with CSF beta -amyloid(1-42) values and entorhinal cortical thickness.ConclusionThis study shows that PUTG component scores were significantly associated with diagnostic group and AD biomarkers, a finding that was more pronounced in APOE epsilon 4 carriers. Replication in independent larger studies and longitudinal follow-up are warranted.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
8.770
2.145
10
19
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Polyunsaturated Fatty-acids; Mild Cognitive Impairment; Surface-based Analysis; Amyloid-beta; Initiative Adni; Composite Score; Gut Microbiota; Apoe Genotype; Brain; Plasma
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0028-3878
e-ISSN 1526-632X
Zeitschrift Neurology
Quellenangaben Band: 94, Heft: 20, Seiten: E2088-E2098 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503891-001
DOI 10.1212/WNL.0000000000009436
WOS ID WOS:000540823800009
Scopus ID 85084888755
PubMed ID 32358220
Erfassungsdatum 2020-06-09
[➜Korrektur melden]