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Seeger, M. ; Soliman, D. ; Aguirre Bueno, J. ; Diot, G. ; Wierzbowski, J.* ; Ntziachristos, V.

Pushing the boundaries of optoacoustic microscopy by total impulse response characterization.

Nat. Commun. 11:2910 (2020)

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Optical microscopy improves in resolution and signal-to-noise ratio by correcting for the system's point spread function; a measure of how a point source is resolved, typically determined by imaging nanospheres. Optical-resolution optoacoustic (photoacoustic) microscopy could be similarly corrected, especially to account for the spatially-dependent signal distortions induced by the acoustic detection and the time-resolved and bi-polar nature of optoacoustic signals. Correction algorithms must therefore include the spatial dependence of signals' origins and profiles in time, i.e. the four-dimensional total impulse response (TIR). However, such corrections have been so far impeded by a lack of efficient TIR-characterization methods. We introduce high-quality TIR determination based on spatially-distributed optoacoustic point sources (SOAPs), produced by scanning an optical focus on an axially-translatable 250nm gold layer. Using a spatially-dependent TIR-correction improves the signal-to-noise ratio by >10dB and the axial resolution by similar to 30%. This accomplishment displays a new performance paradigm for optoacoustic microscopy.

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