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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The stem cell potential of glia: Lessons from reactive gliosis.
Nat. Rev. Neurosci. 12, 88-104 (2011)
Verlagsversion
DOI
PMC
Astrocyte-like cells, which act as stem cells in the adult brain, reside in a few restricted stem cell niches. However, following brain injury, glia outside these niches acquire or reactivate stem cell potential as part of reactive gliosis. Recent studies have begun to uncover the molecular pathways involved in this process. A comparison of molecular pathways activated after injury with those involved in the normal neural stem cell niches highlights strategies that could overcome the inhibition of neurogenesis outside the stem cell niche and instruct parenchymal glia towards a neurogenic fate. This new view on reactive glia therefore suggests a widespread endogenous source of cells with stem cell potential, which might potentially be harnessed for local repair strategies.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
29.510
3.401
272
378
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
central-nervous-system; epidermal-growth-factor; spinal-cord-injury; neural stem/progenitor cells; adult-rat brain; oligodendrocyte precursor cells; subventricular zone astrocytes; bone morphogenetic proteins; in-vitro; cerebral-cortex
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
ISSN (print) / ISBN
1471-003X
e-ISSN
1471-0048
Zeitschrift
Nature Reviews - Neuroscience
Quellenangaben
Band: 12,
Heft: 2,
Seiten: 88-104
Verlag
Nature Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-500800-001
PubMed ID
21248788
DOI
10.1038/nrn2978
Scopus ID
78751677843
Erfassungsdatum
2011-05-10