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Saif, M.* ; Kwanten, W.J.* ; Carr, J.A.* ; Chen, I.X.* ; Posada, J.M.* ; Srivastava, A.* ; Zhang, J.* ; Zheng, Y.* ; Pinter, M.* ; Chatterjee, S.* ; Softic, S.* ; Kahn, C.R.* ; van Leyen, K.* ; Bruns, O.T. ; Jain, R.K.* ; Bawendi, M.G.*

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Nat. Bio. Eng. 4, 801–813 (2020)
Postprint DOI PMC
Open Access Green
Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.Label-free imaging of the endogenous pigment lipofuscin at near-infrared and shortwave-infrared wavelengths enables the longitudinal monitoring of liver injury in mice and in biopsied human livers.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Sudan Black B; Fibrotic Liver; Fibrosis; Autofluorescence; Macrophages; Myofibroblasts; Epidemiology; Inflammation; Prevalence; Apoptosis
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Zeitschrift Nature biomedical engineering
Quellenangaben Band: 4, Heft: , Seiten: 801–813 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London ; New York NY ; Tokyo
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Pioneer Campus
PSP-Element(e) G-510001-001
DOI 10.1038/s41551-020-0569-y
WOS ID WOS:000542072600004
Scopus ID 85086771787
PubMed ID 32572196
Erfassungsdatum 2020-07-08
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