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On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19.
J. Immunother. Cancer 8:e001145 (2020)
The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. In detail, we provide available information on (1) safety regarding the risk of new infections, (2) effects on the outcome of pre-existing infections, (3) whether immunosuppressive drugs used to treat ICI-related adverse events affect the risk of infection or virulence of pre-existing infections, (4) whether the use of vaccines in ICI-treated patients is considered safe, and (5) whether there are beneficial effects of ICIs that even qualify them as a therapeutic approach for these viral infections.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
9.913
1.817
7
8
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Immune Evation ; Review ; T-lymphocytes ; Tumor Escape ; Vaccination; Progressive Multifocal Leukoencephalopathy; Lung-cancer; Therapy; Immunopathology; Immunotherapy; Exhaustion; Expression; Blockade; Defines
Sprache
englisch
Veröffentlichungsjahr
2020
HGF-Berichtsjahr
2020
ISSN (print) / ISBN
2051-1426
e-ISSN
2051-1426
Zeitschrift
Journal for ImmunoTherapy of Cancer
Quellenangaben
Band: 8,
Heft: 2,
Artikelnummer: e001145
Verlag
Bmj Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-500890-001
WOS ID
WOS:000639555700001
WOS ID
WOS:000590727000002
Scopus ID
85087532093
PubMed ID
32611687
Erfassungsdatum
2020-07-07