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Nörder, M.* ; Becker, P.D.* ; Drexler, I. ; Link, C.* ; Erfle, V. ; Guzman, C.A.*

Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.

PLoS ONE 5:e11400 (2010)
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BACKGROUND: Modified vaccinia virus Ankara (MVA), a highly attenuated strain of vaccinia virus, has been used as vaccine delivery vector in preclinical and clinical studies against infectious diseases and malignancies. Here, we investigated whether an MVA which does not encode any antigen (Ag) could be exploited as adjuvant per se. METHODOLOGY/PRINCIPAL FINDINGS: We showed that dendritic cells infected in vitro with non-recombinant (nr) MVA expressed maturation and activation markers and were able to efficiently present exogenously pulsed Ag to T cells. In contrast to the dominant T helper (Th) 1 biased responses elicited against Ags produced by recombinant MVA vectors, the use of nrMVA as adjuvant for the co-administered soluble Ags resulted in a long lasting mixed Th1/Th2 responses. CONCLUSIONS/SIGNIFICANCE: These findings open new ways to potentiate and modulate the immune responses to vaccine Ags depending on whether they are co-administered with MVA or encoded by recombinant viruses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter HUMAN DENDRITIC CELLS; MOUSE BONE-MARROW; RECOMBINANT VIRUSES; IN-VIVO; PLASMA-CELLS; STRAIN MVA; HOST-RANGE; VACCINATION; RESPONSES; IMMUNOGENICITY
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 5, Heft: 6, Seiten: , Artikelnummer: e11400 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-520100-001
G-502700-002
PubMed ID 20628596
DOI 10.1371/journal.pone.0011400
WOS ID 000279370000025
Scopus ID 77955329674
Erfassungsdatum 2010-11-29
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