Wu, F.* ; Cheng, Y.* ; Wu, L.* ; Zhang, W.* ; Zheng, W.* ; Wang, Q. ; Cao, H.* ; Pan, X.* ; Tang, W.*
Emerging landscapes of tumor immunity and metabolism.
Front. Oncol. 10:575037 (2020)
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Cancer ; Metabolism ; Immunity ; Reprogram ; Drug Resistance; T-cell Metabolism; Molecular Pathways; Antitumor Immunity; Glutamine Uptake; Cancer; Memory; Acid; Resistance; Kinase; Expression
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2020
Prepublished im Jahr
HGF-Berichtsjahr
2020
ISSN (print) / ISBN
2234-943X
e-ISSN
2234-943X
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 10,
Heft: ,
Seiten: ,
Artikelnummer: 575037
Supplement: ,
Reihe
Verlag
Frontiers
Verlagsort
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-500390-001
Förderungen
Jiangsu Natural Science Foundation
Copyright
Erfassungsdatum
2020-11-26