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Wu, F.* ; Cheng, Y.* ; Wu, L.* ; Zhang, W.* ; Zheng, W.* ; Wang, Q. ; Cao, H.* ; Pan, X.* ; Tang, W.*

Emerging landscapes of tumor immunity and metabolism.

Front. Oncol. 10:575037 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cancer ; Metabolism ; Immunity ; Reprogram ; Drug Resistance; T-cell Metabolism; Molecular Pathways; Antitumor Immunity; Glutamine Uptake; Cancer; Memory; Acid; Resistance; Kinase; Expression
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 2234-943X
e-ISSN 2234-943X
Zeitschrift Frontiers in Oncology
Quellenangaben Band: 10, Heft: , Seiten: , Artikelnummer: 575037 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Begutachtungsstatus Peer reviewed
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-500390-001
Förderungen Jiangsu Natural Science Foundation
Scopus ID 85093871464
PubMed ID 33117713
Erfassungsdatum 2020-11-26