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Tyser, R.C.V.* ; Ibarra-Soria, X.* ; McDole, K.* ; A Jayaram, S.* ; Godwin, J.* ; van den Brand, T.A.H.* ; Miranda, A.M.A.* ; Scialdone, A. ; Keller, P.J.* ; Marioni, J.C.* ; Srinivas, S.*

Characterization of a common progenitor pool of the epicardium and myocardium.

Science 371:eabb2986 (2021)
Postprint DOI PMC
Open Access Green
The mammalian heart is derived from multiple cell lineages; however, our understanding of when and how the diverse cardiac cell types arise is limited. We mapped the origin of the embryonic mouse heart at single-cell resolution using a combination of transcriptomic, imaging, and genetic lineage labeling approaches. This provided a transcriptional and anatomic definition of cardiac progenitor types. Furthermore, it revealed a cardiac progenitor pool that is anatomically and transcriptionally distinct from currently known cardiac progenitors. Besides contributing to cardiomyocytes, these cells also represent the earliest progenitor of the epicardium, a source of trophic factors and cells during cardiac development and injury. This study provides detailed insights into the formation of early cardiac cell types, with particular relevance to the development of cell-based cardiac regenerative therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 371, Heft: 6533, Seiten: , Artikelnummer: eabb2986 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506290-001
Förderungen British Heart Foundation
DOI 10.1126/science.abb2986
WOS ID WOS:000625876100045
PubMed ID 33414188
Erfassungsdatum 2021-02-08
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