PuSH - Publikationsserver des Helmholtz Zentrums München: Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Qi, L.* ; Cornelis, M.C.* ; Kraft, P.* ; Stanya, K.J.* ; Kao, W.H.L.* ; Pankow, J.S.* ; Dupuis, J.* ; Florez, J.C* ; Fox, C.S.* ; Paré, G.* ; Sun, Q.* ; Girman, C.J.* ; Laurie, C.C.* ; Mirel, D.B.* ; Manolio, T.A.* ; Chasman, D.I.* ; Boerwinkle, E.* ; Ridker, P.M.* ; Hunter, D.J.* ; Meigs, J.B.* ; Lee, C.H.* ; van Dam, R.M.* ; Hu, F.B.*

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.

Hum. Mol. Genet. 19, 2706-2715 (2010)

Verlagsversion Volltext

DOI

PMC

	Closed

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case-control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10,870 cases and 73,735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR=0.90, 95% CI=0.86-0.93; P=3.7x10(-8)). The frequency of the risk-lowering allele T is 0.23. Variants in this region were nominally related to lower fasting glucose and HOMA-IR in the MAGIC consortium (P<0.05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

7.386

2.140

110

158