PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Schlein, C.* ; Fischer, A.W.* ; Sass, F.* ; Worthmann, A.* ; Tödter, K.* ; Jaeckstein, M.Y.* ; Behrens, J.* ; Lynes, M.D.* ; Kiebish, M.A.* ; Narain, N.R.* ; Bussberg, V.* ; Darkwah, A.* ; Jespersen, N.Z.* ; Nielsen, S.* ; Scheele, C.* ; Schweizer, M.* ; Braren, I.* ; Bartelt, A. ; Tseng, Y.H.* ; Heeren, J.* ; Scheja, L.*

Endogenous fatty acid synthesis drives brown adipose tissue involution.

Cell Rep. 34:108624 (2021)
Postprint Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor metabolic health, and BAT reactivation may confer therapeutic potential. However, the molecular drivers of this BAT adaptive process in response to thermoneutrality remain enigmatic. Using metabolic and lipidomic approaches, we show that endogenous fatty acid synthesis, regulated by carbohydrate-response element-binding protein (ChREBP), is the central regulator of BAT involution. By transcriptional control of lipogenesis-related enzymes, ChREBP determines the abundance and composition of both storage and membrane lipids known to regulate organelle turnover and function. Notably, ChREBP deficiency and pharmacological inhibition of lipogenesis during thermoneutral adaptation preserved mitochondrial mass and thermogenic capacity of BAT independently of mitochondrial biogenesis. In conclusion, we establish lipogenesis as a potential therapeutic target to prevent loss of BAT thermogenic capacity as seen in adult humans.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
9.423
1.943
6
13
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Brown Adipose Tissue ; Cardiolipins ; Chrebp ; De Novo Lipogenesis ; Energy Expenditure ; Fatty Acid Synthesis ; Fatty Acids ; Lipidome ; Mitochondria ; Mitophagy ; Non-shivering Thermogenesis ; Phospholipids ; Thermoneutrality ; Triacylglycerols ; Whitening; Element-binding Protein; Diet-induced Thermogenesis; De-novo Lipogenesis; Cardiolipin; Autophagy; Inhibitors; Mice; Ucp1; Physiology; Humans
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 34, Heft: 2, Seiten: , Artikelnummer: 108624 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-251
Förderungen Christine-KatharinaSchmitz-Foundation
Gertraud and Heinz Rose Foundation
UKE MD/PhD program fellowship
German National Academic Foundation
DFG
DACH Gesellschaft f_ur Lipidologie
Deutsches Zentrum fur Herz-Kreislauf-Forschung Junior Research Group grant
Danish Diabetes Academy - Novo Nordisk Foundation
TrygFonden
Deutsche Forschungsgemeinschaft
DOI 10.1016/j.celrep.2020.108624
WOS ID WOS:000607913800021
Scopus ID 85099160502
PubMed ID 33440156
Erfassungsdatum 2021-03-26
[➜Korrektur melden]