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Deshpande, D.* ; Agarwal, N.* ; Fleming, T.* ; Klose, C.S.N.* ; Tappe-Theodor, A.* ; Kuner, R.* ; Nawroth, P.P.

Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

Nat. Commun. 12:426 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neurons in diabetes. In streptozotocin-induced diabetic mice the Pomc promoter is repressed due to increased binding of NF-kB p50 subunit, leading to a loss in basal POMC level in peripheral nerves. Decreased POMC levels are also observed in peripheral nervous system tissue from diabetic patients. The antinociceptive pathway mediated by POMC is further impaired due to lysosomal degradation of μ-opioid receptor (MOR). Importantly, the neuropathic phenotype of the diabetic mice is rescued upon viral overexpression of POMC and MOR in the sensory ganglia. This study identifies an antinociceptive mechanism in the sensory ganglia that paves a way for a potential therapy for diabetic neuropathic pain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Proopiomelanocortin Gene-expression; Peripheral Sensory Neurons; Factor-kappa-b; Opioid Receptor Phosphorylation; Kinase-c Isoforms; Beta-endorphin; Metabolic Dysfunction; Channel Function; Met-enkephalin; Ion-channel
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 426 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-251
Förderungen Projekt DEAL
DOI 10.1038/s41467-020-20677-0
WOS ID WOS:000625194400001
WOS ID WOS:000611511500004
Scopus ID 85099593508
PubMed ID 33462216
Erfassungsdatum 2021-02-08
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