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Dommel, S.* ; Blüher, M.

Does C-C motif chemokine ligand 2 (CCL2) link obesity to a pro-inflammatory state?

Int. J. Mol. Sci. 22:1500 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The mechanisms of how obesity contributes to the development of cardio-metabolic diseases are not entirely understood. Obesity is frequently associated with adipose tissue dysfunction, characterized by, e.g., adipocyte hypertrophy, ectopic fat accumulation, immune cell infiltration, and the altered secretion of adipokines. Factors secreted from adipose tissue may induce and/or maintain a local and systemic low-grade activation of the innate immune system. Attraction of mac-rophages into adipose tissue and altered crosstalk between macrophages, adipocytes, and other cells of adipose tissue are symptoms of metabolic inflammation. Among several secreted factors attract-ing immune cells to adipose tissue, chemotactic C-C motif chemokine ligand 2 (CCL2) (also de-scribed as monocyte chemoattractant protein-1 (MCP-1)) has been shown to play a crucial role in adipose tissue macrophage infiltration. In this review, we aimed to summarize and discuss the current knowledge on CCL2 with a focus on its role in linking obesity to cardio-metabolic diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adipokine ; Adipose Tissue ; Chemokine ; Inflammation ; Obesity
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 22, Heft: 3, Seiten: , Artikelnummer: 1500 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506501-001
Förderungen Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
DOI 10.3390/ijms22031500
WOS ID WOS:000615319100001
Scopus ID 85100264222
PubMed ID 33540898
Erfassungsdatum 2021-04-14
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